Nanotechnology offers A variety of options to lead to biology. Below I'll existing illustrations wherever nanofabrication – a chance to make confined buildings with Proportions at will – is made use of to look at the biophysics of one molecules and cells. I'll existing some illustrations from our lab:
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Deposition and atomic force microscopy of person phthalocyanine polymers between nanofabricated electrodes
2010, made a new way (‘wedging transfer’) to manipulate nanostructures; 1st report of DNA translocation by graphene nanopores; and understood hybrid nanopores by directed insertion of α-hemolysin into good-point out nanopores
SMC complexes can pass physical roadblocks larger than their ring dimensions, indicating a nontopological mechanism for DNA loop extrusion
Size control of personal carbon nanotubes by ceesdekker nanostructuring With all the scanning tunneling microscope
Case in point (1) of bending configurations in 3D simulations of DNA rods on nanopores. A percentage of the membrane is demonstrated in gray, the rim on the pore is highlighted in red, plus a 3D rendering of the movement of your DNA rod is shown.
The rotors harness Strength from a nanoscale h2o and ion circulation which is generated by a static chemical or electrochemical opportunity gradient while in the nanopore, which can be established via a salt gradient or applied voltage, respectively. These synthetic nanoengines self-Arrange and operate autonomously in physiological ailments, suggesting approaches to constructing Electricity-transducing motors at nanoscale interfaces.
Bulk-floor coupling identifies the mechanistic link amongst Min-protein designs in vivo and in vitro
Screening pseudotopological and nontopological products for SMC-pushed DNA loop extrusion against roadblock-traversal experiments
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2004, discovery of latest physics in translocation of DNA via nanopores; to start with experimental review of ions conduction in nanofluidic channels; very first electrochemistry with individual solitary-wall carbon nanotubes; STM detection and control of phonons in carbon nanotubes; initially electrical docking of microtubules on kinesin-coated nanostructures; 1st biophysics characterization of the mechanical Attributes of double-stranded RNA; and very first one-molecule examine of DNA translocation by a restriction-modification enzyme.